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Tulsi Ghimire was born in Sindeybong, Kalimpong, Darjeeling district, India to Nepali parents Dhojman Ghimire and Narbada Ghimire. He has two younger brothers and a sister. Tulsi studied at the Mani Memorial Primary School in Sindeybong up to second grade, and then from grade 3 to 11 at the Scottish University Mission Institute (SUMI), Kalimpong. He obtained a Bachelor of Arts degree from Kalimpong College. He is married to Bharati Ghimire (Gazmer), who has sung in many of his films. His brother Shrawan Ghimire is a successful film producer. Tulsi's children, Bhawana Ghimire and Panchami Ghimire, have also appeared in a Nepali children's film Swarg Ko Pari.